West German Lymphoma Symposium

Day 1 | Friday, 24th May 2024

from 09:30

Registration

10:45

Welcome
Scientific committee

11:00-1:00

Session 1
The germinal center reaction as
a catalyst for lymphoma development

Chair

Christian Reinhardt
University Hospital Essen (GER)

11:00

Role of Super-enhancer
Hypermutation in the
Pathogenesis of Diffuse
Large B cell Lymphoma
Riccardo Dalla-Favera,
Columbia University New York (USA)

11:25

Genetics-driven epigenetic disruption
of the germinal center program
in B cell lymphomas
Laura Pasqualucci,
Columbia University New York (USA)

11:50

Aspects of Hodgkin lymphoma biology
Ralf Küppers,
University Hospital Essen (GER)

12:15

Modelling Sporadic Oncogenic Events
in Lympho magenesis
Dinis Calado,
The Francis Crick Institute London (UK)

12:40

Short talk I –
Immunosurveillance of
Precancerous Germinal
Center B Cells
L. Zhang,
The Francis Crick Institute London (UK)

12:50

Discussion

1:00-2:00

Break

2:00-4:00

Session 2
Epigenetic rewiring as a driver
and target of lymphomagenesis

Chair

Peter Borchmann
University Hospital Cologne (GER)

2:00

Mechanisms and therapeutic targeting
of the malignant immune system
Ari M. Melnick,
Weill Cornell Medicine New York (USA)

2:25

Development of small molecules
for epigenetic targets
Stefan Knapp,
Goethe-University Frankfurt (GER)

2:50

Harnessing state switches
in aggressive B-cell lymphoma
Clemens Schmitt,
Charité – University Hospital Berlin (GER)

3:15

DNA-methylation based classification
of lymphomas: A tool to come?
Reiner Siebert,
Ulm University Hospital (GER)

3:40

Short talk II –
Targeting N-linked
Glycosylation for the
Therapy of Aggressive
Lymphomas
S. Scheich

3:50

Discussion

4:00-6:00

Poster presentation and
Get together

The Influence of HIV on the B Cell System
and Lymphomagenesis
V. Berg,
University Hospital Essen (GER)

B Cell Differentiation in the Germinal
Centre Reaction
A.-K. Schnormeier,
University Duisburg-Essen (GER)

DSMZCellDive: a web tool for browsing
and analyzing transcriptomic data of
hematological cell lines
S. Nagel,
Leibniz-Institute (GER)

Distinct chemokine receptor expression
profiles in the development and early
progression of follicular lymphoma
A. Zupo,
Medical University of Graz (AUT)

Functional vs. Genomic-based Precision
Medicine in Hematological Cancers:
Feasibility Analysis of the EXALT-2 Study
L. Kazianka,
Medical University of Vienna (AUT)

Deep learning-based classification of
diffuse large B-cell lymphoma cell-of-
origin by gene expression profiles
K. Kundal,
Indian Institute of Technology Hyderabad (IND)

LUBAC activity is required for ABC-DLBCL
pathogenesis
D. Bonasera,
University of Cologne (GER)

A rationale for dual PIM and PI3K
inhibition in peripheral T-cell lymphoma
M. Lohrberg,
University Medical Center Göttingen (GER)

Senolytic capacity of obinutuzumab in
t(14;18)-positive GCB DLBCL
M. Stegemann,
Kepler University Hospital (AUT)

Identification of ferroptosis sensitizers for
DLBCL treatment
J. Labisch,
University Hospital Münster (GER)

In vitro secretome analysis of primary
CLL cells and genetically modified B cells
L. Osswald,
Technial University of Munich (GER)

Modulation of tumour microenvironment
by BIRC3-loss-of-function in CLL
S. Lyu,
University of Cologne (GER)

Brusatol synergizes with venetoclax to
induce cell death in aggressive
lymphomas both in vitro and ex vivo.
M. M. Szmyra-Połomka,
Medical University of Graz (AUT)

Detection of occurrent somatic
hypermutation and associated gene
expression profile in single follicular
lymphoma B cells
H. Veelken,
Leiden University Medical Center (NDL)

Unveiling Follicular Lymphoma’s
Common Progenitor Cells
O. Atkins,
The Francis Crick Institute (UK)

Molecular analysis of B-cell dysfunction in
patients with chronic lymphocytic
leukemia (CLL)
M. Dampmann,
University Hospital Essen (GER)

Understanding the role of cFLIP in the
pathogenesis of Diffuse Large B Cell
Lymphoma
K. T. Bariboloka,
University Hospital Cologne (GER)

Machine-learning based body
composition analysis in patients
receiving CD19-directed CAR-T cell
therapy
F. Ullrich,
University Hospital Essen (GER)

An In Vivo PiggyBac Insertional
Mutagenesis Screen Reveals Oncogenic
Lesions Cooperating With Myd88^L265P
S. Höfmann,
University Hospital Essen (GER)